EASING ACCESS
TO THE NEXT-GENERATION
OF OSD DRUG PRODUCT CONTROL

Addressing today’s and tomorrow’s
quality control challenges

As the pharmaceutical industry shifts from batch to continuous manufacturing, conventional quality control methods are no longer sufficient to meet rising regulatory expectations for better control of OSD drug product quality.

Anticipating this evolution more than five years ago, Pharma Technology began developing versatile solutions that integrate advanced Process Analytical Technologies (PAT) to monitor and control Critical Quality Attributes (CQAs).

By combining multidisciplinary scientific expertise, our R&D team has designed equipment that makes advanced quality control more accessible, supporting the industry’s move towards Quality by Design and real-time process understanding.

Discover the Q-Control family

Advanced PAT solutions designed to accelerate formulation development and deliver real-time process understanding.

CUB-X

CU-120

CW-150

CQA analysis

Depending on your specific application and quality control objectives, our solutions can monitor and control different sets of Critical Quality Attributes (CQAs), using either destructive or non-destructive analytical approaches. This flexibility allows pharmaceutical companies to select the most appropriate methodology according to their product characteristics, development stage, and manufacturing environment.

Our systems are designed with scalability and adaptability in mind. As regulatory expectations evolve and new CQAs need to be measured or predicted, the platform can be upgraded with additional analytical capabilities, software functionalities, or chemometric models. This ensures that our solutions not only address today’s quality control requirements but are also prepared to support the future needs of pharmaceutical development and manufacturing.

Embedded technologies

We integrate the most advanced technologies into our quality control solutions and make them easy to use through carefully designed software interfaces.

Advanced analytical technologies used for pharmaceutical quality control are often perceived as complex and difficult to implement, which can discourage their adoption. Pharma Technology develops QC solutions designed to reshape how these technologies are used in oral solid dosage (OSD) product development and manufacturing by making them more accessible, practical, and reliable.

4P Tester

3D Microwave

NIR-SRS

3D Laser

Expert support for tailored control solutions

Because every process involves unique parameters and each product comes with its own set of critical attributes to monitor, our scientific experts support you in building tailored chemometric models adapted to your specific application.

Quality control challenge understanding:

Pharma Technology begins every collaboration by gaining a clear understanding of the quality control challenges faced by the client. By analysing the product characteristics, the manufacturing process, and the Critical Quality Attributes (CQAs) that need to be monitored, our scientific team identifies the most relevant analytical approach. This initial assessment allows us to configure the CUB-X platform and develop the appropriate chemometric models to address the client’s specific application and ensure reliable, actionable quality control.

Frequently asked questions

Here are some common questions about our Services

How easy is to implement PT CQAs analyser in an existing process?

Shop-floor integration: Thanks to OPC UA connectivity and the flexibility of our machines, integration into an existing manufacturing line is straightforward and can be tailored to the specific type of production line. Operating according to the Quality by Design (QbD) principle, our analysers can transmit real-time data to upstream process steps, helping maintain the process within the defined design space specifications.

Machine operation: Pharma Technology is more than an equipment supplier; we provide a complete solution that includes installation support and operator training. Depending on the level of chemometric expertise available in-house, our specialists can also provide additional application and data-analysis support to ensure successful implementation and long-term performance.

Which Critical Quality Attributes can be measured?

Both versions, CUB-X and CU-120 can measure the same CQAs but at different speeds:

· Mass

· Thickness

· Api Fraction + Assay

· Content Uniformity

· Moisture

· Porosity

· Hardness (destructive or non-destructive way)

· Diameter / Length

What is NIR-SRS technology, and what are its main benefits?

NIR-SRS (Near-Infrared Spatially Resolved Spectroscopy) is a multipoint NIR technique designed to collect as much spectral information as possible from a sample, such as a pharmaceutical tablet.

The sample is illuminated with polychromatic near-infrared light, and the diffusely reflected light is collected by nine collimating optical fibers. Because the fibers are arranged at different positions within the probe, each fiber has a different angle and distance relative to the sample surface. This configuration enables the acquisition of spatially resolved spectra from multiple regions of the sample.

Compared with conventional single-point NIR measurements, NIR-SRS provides substantially richer spectral information, improving the characterization of sample heterogeneity and surface properties.

How can Pharma Technology's CQA analysers support the implementation of a Real-Time Release Testing (RTRt) strategy?

Pharma Technology's CQA analysers enable automated, high-speed tablet inspection, delivering results fast enough to support real-time decision-making. By continuously monitoring critical quality attributes throughout the manufacturing process, they allow quality to be verified in real time rather than through traditional end-of-batch laboratory testing, which is needed for implementing a robust RTRt strategy.

Are Pharma Technology CQA analysers GMP-compliant

Yes both versions, CUB-X and CU-120 are fully CGMP compliant.

The CUB-X has an additional working mode called LAB Mode which allow the R&D people to work more freely without the cGMP requirements and being able to do quick trials, experiments, proof of concepts, etc..

How does pharmaceutical manufacturing equipment communicate with other systems like MES or LIMS?

Pharma Technology's Q-Control equipment can be seamlessly integrated into existing plant IT/OT infrastructure through OPC UA (Open Platform Communications Unified Architecture) connectivity. This industry-standard, vendor-neutral communication protocol enables secure, real-time data exchange between quality control instruments and higher-level systems such as MES, LIMS, SCADA, and data historians.

Thanks to this connection, measurement data, critical quality attribute (CQA) results, and equipment status can be automatically transmitted to the plant's existing digital architecture, eliminating manual data transfer, reducing the risk of transcription errors, and supporting compliance with data integrity requirements (e.g., 21 CFR Part 11). This integration facilitates real-time monitoring, streamlined batch record management, and faster decision-making across the manufacturing process.

Scientific resources

Check out our latest research publications !